![]() ![]() We therefore screened a panel of diverse cisplatin analogs and identified compounds that conferred protection from cyanide poisoning in zebrafish, mice and rabbits. The binding affinity of the cyanide anion for the positively charged metal platinum is known to create an extremely stable complex in vitro. Current antidotes exhibit limited efficacy and are not amenable to mass distribution requiring the development of new classes of antidotes. Cyanide kills organisms as diverse as insects, fish and humans within seconds to hours. Here we describe a role for this small molecule in cyanide detoxification in vivo. Cisplatin holds an illustrious position in the history of chemistry most notably for its role in the virtual cure of testicular cancer. ![]()
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